Abstract : To describe the clinical and epidemiological features of Multiple Sclerosis in Ninevah governorate, Iraq. In this case series study, we included 418 Iraqi patients with clinically definitive MS (diagnosed by using McDonald criteria) attending regularly the Multiple Sclerosis Clinic in “Ibn Sina Teaching Hospital” (Mosul; Iraq) from January 2022 to June 2022. We measured the functional status of the patients by using “Kurtzke Expanded Disability Status Score” (EDSS). The ratio of MS is predicted to be 10.3 per 100,000, with annual incidence ranging from 4.6 to 11.57 per million last 4 years. The average age at the onset of symptoms was 27.7±9.9 years, with an average duration of symptoms of 7.2±6.9 years. Women are two times more likely to be diagnosed with MS with a female-male ratio of 1:0.6. Sensory symptoms (26%) than visual (20%) and motor (18.5%) symptoms were the most common initial clinical pattern of the disease. The subtype of clinical presentation of MS was relapsing-remitting MS in 82.8% of cases, secondary progressive MS in 14.2%, and primary progressive MS in 3%. The distribution of functional disability by EDSS showed that 68.5%, 25.4% and 6.1% present with the mild, moderate and severe forms, respectively. Our findings were similar to studies done in different countries of the middle east regarding the age of onset, clinical pattern and disability from the disease, but the prevalence of MS in this study was relatively lower than in neighbouring countries which could be due to limited tools for diagnosing MS, underestimation of this disease by a different medical specialist, and the limited number of neurologists.