Abstract : Lifestyle medicine focuses on evidence-based lifestyle interventions as a cornerstone in the prevention and management of chronic diseases. With the increasing prevalence of non-communicable diseases in the world, the approach to healthcare has changed from treatment to prevention. Integrating lifestyle interventions into routine clinical practice may significantly reduce disease burden, improve population health outcomes, and enhance the sustainability of healthcare systems. Lifestyle medicine should be considered a fundamental component of modern preventive healthcare strategies. This study summarizes current scientific evidence on the role of lifestyle medicine in preventing chronic diseases, with a focus on cardiovascular disease, type 2 diabetes, obesity, mental health disorders, and cancer. It reviews evidence-based lifestyle interventions and discusses their potential application in modern healthcare systems. The reviewed literature demonstrates that lifestyle medicine interventions are strongly associated with reduced risk of metabolic and cardiovascular chronic diseases. Evidence indicates that dietary modifications, regular physical activity, adequate sleep, stress management, and avoidance of harmful substances significantly reduce the incidence of cardiovascular diseases, type 2 diabetes, obesity, and mental health disorders. Multiple studies support the effectiveness of comprehensive lifestyle interventions in improving metabolic parameters, mental well-being, and overall quality of life.