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Abstract : Obesity is one of the causative agents in progression of many diseases as diabetes mellitus, cardiovascular diseases, hypertension and others. It may be considered as one of the danger factor increasing the morbidity and death rate during Covid-19 pandemic. The aim of this study is to examine the correlation between obesity and its associated biochemical mechanisms in patients with a confirmed COVID-19 diagnosis. To assess if obesity increases the severity of Covid-19 or not; 80 individuals (40 male and 40 female) aging (35 – 40 years old) suffered from Covid-19 with different body weight (normal and obese) were enrolled in this study. Estimation of blood pressure, leptin hormone, pro and anti-inflammatory cytokines, glycemic indices and lipid profile were performed to differentiate and understand the biochemical abnormalities between normal and obese survivors. Obesity increased levels of blood pressure, un-preferred lipid fractions, fasting blood glucose, insulin, HOMA-IR, leptin hormone and pro-inflammatory cytokines in both male and female subjects with significant decrement in anti-inflammatory cytokine content in comparison with normal weighed survivors (p≤0.05). Obesity worsen the biochemical changes in survived individuals in comparison to normal weighed ones and this may increase the mortality and morbidity of Covid-19 pandemic among obese persons.