Abstract : Impaired fasting glycaemia (IFG) is a condition, in which a person's fasting blood glucose levels are consistently higher than the normal range, but below the diagnostic cut-off for diabetes mellitus (DM). ß-cell dysfunction and insulin resistance (IR) have a principal role in the pathogenesis of IFG. Patients with IFG are at high risk of progression to diabetes, and developing atherosclerotic cardiovascular disease (ASCVD), The present study was designed, to determine the degree of IR (HOMA-IR) and ß-cell dysfunction (HOMA-B) among patients with IFG, and also to correlate HOMA-IR and HOMA-B with biochemical and anthropometric variables. The study included 143 patients with IFG, 61 males and 82 females, 14 – 70 years of age, and 150 apparently healthy subjects, 62 males and 88 females, 15-70 years age as a control group. Physiological measurements include weight, height, waist circumference (WC), and blood pressure (BP). Biochemical measurements include fasting blood glucose (FBG), glycated haemoglobin (HbA1c), insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C). In addition, HOMA-IR and HOMA-B were also determined. Insulin level was significantly higher among patients with IFG in comparison to control subjects, (P < 0.000). There were no significant differences in FBG and HbA1c between IFG and control group, (P > 0.05). Concerning HOMA-IR and HOMA-B, patients with IFG showed a significantly higher HOMA-IR and a significantly lower HOMA-B values compared to control subjects, (P = 0.000). LDL-C was significantly higher among patients with IFG in comparison to control subjects, (P < 0.05). There were no significant differences in TC, TG and HDL-C between the two groups, (P > 0.05). Correlation analysis in patients with IFG revealed a positive correlation of HOMA-B with insulin, (P < 0.01) and a significant negative correlation with LDL-C, (P < 0.01). While, HOMA-IR showed a significant positive correlation with insulin, (P < 0.01), FBG (P < 0.01) and TG (P < 0.05). We concluded that patients with IFG have significantly higher insulin and HOMA-IR and significantly lower HOMA-B values compared with control subjects. This indicates that these patients are a high risk of progressing to T2D and its complications. In addition, the significantly higher LDL-C among patients with IFG in comparison to control persons may increases the risk of macro-vascular ASCVD.