Abstract : In-hospital cardiac arrests are critical emergencies that demand immediate intervention to maximize patient survival rates. However, these events are not confined to clinical areas and can occur in non-clinical areas of the hospital. Recognizing this critical gap, the need to empower non-healthcare workers with the skills to perform basic life support has become increasingly evident. This study aimed to evaluate the effectiveness of a novel training program designed to equip non-healthcare workers with the ability to recognize cardiac arrest, initiate code blue, and perform hands-only CPR. This prospective, interventional cohort study was conducted over a period of 18 months in Ramaiah memorial hospital. A sample size of 329 participants consisting of administration, housekeeping and maintenance staff were selected based on our inclusion and exclusion criteria for the study. The training program was divided into three sessions, each consisting of both video-based and hands-on practical training focused on the key steps of hands-only CPR. The effectiveness of the training was evaluated through pre- and post-assessment of knowledge and skills using a structured 10-question multiple-choice questionnaire and practical demonstrations. Data were analyzed using statistical methods including paired t-tests and McNemar tests. 71.1% of the participants scored <80% during the pre-assessment compared to 88.4% who scored >80% after intervention which was statistically significant. (p value<0.001). On assessment of knowledge, pre-test it was found that 20.36% of the participants had score of 3/10 and post-test 25.55% of the participants scored 7/10. The study conducted demonstrated simple and effective hands-only CPR training for non-health care workers. By implementing such training programs, hospitals can significantly enhance their overall preparedness for in-hospital cardiac arrests, particularly in non-clinical areas, thereby improving patient outcomes.