Abstract : The objective of this research was to determine the histopathological effects of a local strain of Toxoplasma Gondii isolated from fetuses of aborted ewes on the eyes and brains of rat fetuses. T. Gondii diagnosed in the fetuses of aborted ewes. Inject near 100 tissue sacs of Toxoplasma intraperitoneal into 20 pregnant rats in the first week of gestation. The cyst of T. Gondii and its influence on the rat's fetus eyes and brains were investigated histopathologically using light microscopy on their eyes and brains. On histopathological analysis of the eye tissue of parasite-infected rat fetuses, the result of the ocular cerebral toxoplasmosis model is seen. The presence of necrosis of the outer germinal layer and the inner layer in the newborn eye of the Toxoplasma infected group. The toxoplasma-infected group's brain reveals focal glial cell aggregation (Gliosis), vacuolar degeneration, severe cytogenic edema, liquefactive necrosis, and gliosis in the cortex of the cerebrum. rat's fetuses can be utilized as a model for congenital ocular cerebral toxoplasmosis, and they can also be used as a model for toxoplasmosis after 18 days of pregnancy, according to the findings of this study.