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Abstract : Post-anesthesia complications, including shivering, pain, nausea and vomiting are among the most common complaints of patients undergoing general anesthesia. Dexmedetomidine (DMET) is an agent abundantly applied to reduce these complications; however, the best dosage remained a question. The current study aims to investigate different doses of DMET for management of postoperative shivering, pain, nausea and vomiting in laparoscopic cholecystectomy. The current randomized clinical-trial (RCT) has been conducted on 76 patients undergoing laparoscopic cholecystectomy who were randomly assigned into three groups of low-dose DMET (0.3 µ/kg) (n=25), high-dose DEMT (0.5 µ/kg) (n=25) or normal saline (control group) (n=26). The patients’ vital signs and postoperative complications were assessed every 15 minutes during and after the surgery, within 6, 12, 18 and 24 hours after it. The assessments of shivering showed that high dose DEMT led to statistically lower scores than the other two groups (P-value<0.05). Significant pain improvement was noted in all the groups (P-value<0.05), while treated patients with high dose DMET represented lower pain scores (P-value<0.05). Significant improvement in postoperative nausea and vomiting was noted in the control group only (P-value<0.05). The pain scores were remarkably higher in the control group (P-value<0.05) compared to the others; however, low versus high dose DMET did not differ (P-value>0.05). DMET administration was accompanied by significant postoperative shivering, pain, nausea and vomiting control. Besides, superior outcomes with negligible adverse effects were generally, achieved by the application of 0.5 μg/kg than 0.3 μg/kg.