Abstract : Endometriosis is a hormone-dependent condition of cells growing outside the uterus that cause infertility and chronic pain in women. It is majorly caused by inflammation and failure of cell apoptosis. The objective of this study is to evaluate the effect of flavonoids extracts from P. macrocarpa fruit in treating endometriosis via pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins. Endometriosis mice model induced by DMBA were treated with Phaleria macrocarpa fruit extracts at dose 3.75 mg/day, 7.5 mg/day, 11.25 mg/day, and 15 mg/day for 14 days. Following treatment, Bax and Bcl-2 level was tested from peritoneal fluid. High expression of Endometriosis mice model showed lesions in peritoneal tissue also high expression of ER-α and ER-β. Treatment with flavonoids extracted from P. macrocarpa fruit successfully improved Bax pro-apoptotic protein in the endometriosis mice model. Treatment with flavonoids of P. macrocarpa could reduce endometriosis cell survival which is observed from low Bcl-2. Administration with 15 mg/day of flavonoids extracts of P. macrocarpa fruit showed as the most optimum.