Abstract : This study aimed to compare the intranasal administration of midazolam and dexmedetomidine in uncooperative children with cerebral palsy. The sample consisted of 20 children with cerebral palsy aged 5 to 11 years who were divided equally into two groups: Group 1 (experimental) nasal dexmedetomidine 1 mcg/kg and Group 2 (control) nasal midazolam 0.2 mg/kg. The efficacy of both drugs was evaluated according to Ohio State University OSUBRS behavioral rating scale, the University of Michigan scale UMSS, and the Houpt general behavior scale. Both Drugs have been effective in the management of children with cerebral palsy. There were no statistically significant differences for Ohio State University OSUBRS behavioral rating scale (p = 0.301), the University of Michigan scale UMSS (p = 0.403), and the Houpt general behavior scale (p = 0.185). There were no clinically significant changes in vital signs throughout the study. Both nasal midazolam and dexmedetomidine can be used as sedative drugs in the management of children with cerebral palsy during dental treatment.