E-learning is increasingly implemented during the COVID-19 pandemic. This wide implementation caused the need to investigate e-learning effectiveness. Therefore, this study was undertaken to investigate the effectiveness of electronic educational course about Special Care Dentistry (SCD) in improving the learning of undergraduate dental students. And measure participants’ perceptions towards the course. About 13 undergraduate dental students (n=13) were accepted to participate in the educational course. Learning management System (LMS) of Syrian Virtual University was utilized to host the course. A pre/posttest questionnaire consisting of 50 identical multiple-choice questions was used to assess the knowledge of participants before and after the course. A questionnaire consisting of 26 items was also used to assess the attitude of students towards the electronic course in terms of ease of use and acquired usefulness. Descriptive statistic, Wilcoxon Signed Ranks Test, Cronbach’s Alpha Coefficient were used. Significance value of 0.05 was considered statistically significant. The results showed an improvement in the acquired knowledge where the average score of students in the pretest is 13.69 with a standard deviation of 3.816, while the average score of students in the posttest is 86.31 with a standard deviation of 5.345. The learners considered that this course is easy to use and useful. So This study suggested that the e-learning can be effective for improving knowledge of undergraduate dental students.