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Abstract : Many diseases and syndromes are associated with oral manifestations, as in the case of lymphoma. This study aimed to investigate the oral manifestations of Hodgkin's lymphoma patients at Tishreen University Hospital. This study included 230 patients with Hodgkin’s lymphoma attending Tishreen University Hospital in Lattakia from September 2019 to September 2022 and 230 healthy patients. The patients were selected based on clinical findings and study conditions. The study objectives and work procedures were explained, and written informed consent was obtained from all patients who participated in the study. The swelling within the oral cavity, taste changes, and opportunistic infections were recorded. Data were analyzed with the chi-square test. The incidence of swelling inside the oral cavity was 15.2%, and 0% in the experimental and control group respectively with a statistically significant difference (p=0.002). The incidence of changes in taste was 17.8%, and 7.4% in the experimental and control group respectively with a statistically significant difference (p=0.002). The incidence of opportunistic infections was 38.7%, and 17.8% in the experimental and control group respectively with a statistically significant difference (p=0.000). Swelling inside the oral cavity, changes in taste, and opportunistic infections can be considered oral manifestations associated with Hodgkin's lymphoma.