Abstract : Osteoporosis (OP) is a common complication of liver cirrhosis. It can cause morbidity and mortality due to high fracture risk and impaired quality of life. is to assess the frequency of OP among patients with liver cirrhosis and to find risk factors associated with it. Between January 2020 and February 2021, patients who had liver cirrhosis or newly diagnosed with cirrhosis were arranged to do bone mineral density (BMD), BMD was measured by dual-energy X-ray absorptiometry (DEXA) at the lumbar spine and femoral neck. Osteopenia and osteoporosis were defined according to WHO criteria, after taking informed oral consent followed by full history, examination and demographic data. A total of 150 patients (males 108(72%) and females 42(28%)) with a mean age of 50.85+_12.9 years were enrolled in this study. Prevalence of OP was found to be 46.6% (70/150). On multivariate analysis, child-Pugh classification, menopausal state and body mass index(BMI) were significantly associated with OP, while age, gender and etiology of cirrhosis were non significantly found to be associated with OP. Low BMD is highly prevalent in patients with chronic liver disease(CLD) of variable etiologies and commonly overlooked. We advocate more randomized and prospective studies to be conducted on homogeneous groups with CLD in its various stages. In view of numerous therapeutic options available both for liver disease and bone disease, it is prudent to characterize this condition in order to give these patients a better chance of survival with good quality of life.