Abstract : Bisphenol A (BPA) is a phenolic organic compound commonly used in manufacturing plastics. A relationship between BPA and attention deficit hyperactivity disorder (ADHD) has been discussed. To assess the role of BPA. A prospective case-control study was conducted on 60 children. Children were divided into two equal groups. Group (I) children diagnosed with ADHD. Group and Group (II) healthy control children. Full history, examination, the Conners’ Parent Rating Scale (CPRS), and the Stanford-Binet Intelligence Scale were applied for each child. One spot urine sample was collected from each participant and tested by High-performance liquid chromatography (HPLC) for BPA concentrations. Significant differences between the control group and case group regarding the type of feeding and food/water storage in plastics and also learning disabilities were detected. All case group participants had significantly higher urinary BPA concentrations than the control group. Food/water storage in plastics was a significant predictor of increasing urinary BPA There was a statistically significant positive correlation between urinary. BPA exposure can markedly affect the appearance of ADHD symptoms in children.