Abstract : The aim of this experiment is detect the leptin levels and cholesterol levels and other lipid profile parameters in children with giardiasis. The current experiment was done among children aged 7 years to 13 years in Kirkuk city. The feces and blood samples collected from Children's Hospital between May to end of October 2021. 80 children used in current, who diagnosed with acute watery diarrhea and abdominal pain. The outcomes of this experiment demonstrated significant (P<0.05) decreased in levels of leptin in infected children compared with healthy children. Total cholesterol, triglyceride and high density lipoprotein (HDL) exhibited significant (P<0.05) decreased in infected children compared with healthy. While, the results of low density lipoprotein (LDL) and very low density lipoprotein (VLDL) in infected children demonstrated significant (P<0.05) reduce compared with healthy children. So, the infection with giardiasis leads to decrease leptin levels and cholesterol levels and other lipid profile parameters in children.