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Abstract : In a rapidly changing era, improving adolescent health literacy, especially in the context of HIV/AIDS prevention, is important. The use of virtual reality applications can help change their perception of risk and precautions. It also meets the needs of teenagers who are increasingly connected to technology in the digital age. This study uses time series non-equivalent control group design. Large samples in the intervention group and control group were 44 people each (a total of 88 people). The sampling technique is carried out by consecutive sampling. Health Literacy questionnaire for prevention of HIV / AIDS with a Virtual Reality-based Health Belief Model (HBM) approach. This study was conducted for approximately 2 months, from June to August 2023. There is an influence of the health literacy model using virtual reality on perceived severity and perceived susceptibility about HIV/AIDS in adolescents in Pangkajene Regency and Islands, as well as an increase in positive perceptions of HBM: the benefit of HIV/AIDS prevention in the intervention group (VR) is higher than in the control group. the positive influence of Health Literacy and VR media in improving perceptions of benefits related to HIV/AIDS prevention among adolescents, which has important implications in changing disease prevention behaviour.