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Abstract : Theoretically, a single HD session could improve lung function by improving uremia and metabolic acidosis, and eliminate pulmonary edema by removing fluid by ultrafiltration. The aim of this study was to investigate changes in lung function after a course of HD treatment in patients with ESRD, using spirometry. Fifty seven ESRD patients undergoing chronic hemodialysis were studied. Pulmonary function test by spirometric test were performed before and after one single session hemodialysis. The average age of all patients was 47.08 ± 14.1 years (range: 19-77 years). Of the 57 patients, 32 (56.1%) were men and 25 (43.9%) were women. There were 18 (31.6%) patients who had a history of smoking and 39 (68.4%) patients who did not have a history of smoking. The average FVC for all patients was 34.76 ± 19.55 predicted, where this figure increased to 36.81 ± 17.92 predicted after HD, but this increase was not statistically significant (P>0.05). The average FEV1 for all patients was 38.52 ± 20.90 predicted, where this figure increased to 40.69 ± 18.81% predicted after HD, but this increase was not statistically significant (P>0.05). The average FEF25 for all patients was 65.10 ± 44.58% predicted and 1.17 ± 0.82, where this figure increased to 78.19 ± 39.94 predicted and 1.24 ± 0.78 after HD, but this increase was not statistically significant (P>0.05). In patients with ESRD who are on chronis hemodialysis, hemodialysis may improve lung function parameters on spirometry. Larger studies are needed to better understand the plausible impact of hemodialysis on spirometric parameters.