Cross-infection in dentistry is a problem that unfortunately occurs in many ways, and mobile phones have rightly been cited as the cause of several cross-infections. This study aimed to assess the effec-tiveness of CaviWipes™ in disinfecting contaminated mobile phones among dental students during their clinical training, at Tishreen University, Syria. Samples were taken from 150 students' mobile phones with sterile cotton swabs. Two swabs were taken, the first one before and the second after wiping the devices with CaviWipes™. All samples were cultured directly on Nutrient agar (Merck, Germany), Blood agar (Merck, Germany), Eosin Methylene Blue (EMB) (Merck, Germany). Gram staining, morphology of bacteria, catalase reaction and oxidase reaction were used to identify the collected microorganisms. Data were statistically analyzed using Paired t-test. The study showed that microbial growth was 100% in all samples from cellular phones, and a significant difference was found between Colony Forming Units (CFU) before and after wiping the devices with CaviWipes™ (P<0.05). CaviWipes™ were 96.5% effective in reducing bacterial growth. Among the detected bac-teria, only gram-spore forming bacilli were resistant to CaviWipes™. Within the limitations of the present study, it appears that the use of CaviWipes™ as a disinfectant could reduce bacterial growth on dental students' phones significantly.