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Abstract : It was suggested that oral haloperidol may be effective in managing the manifestations of psychotic disorders, and severe behavioral problems in children with hyperactivity. Therefore, this study aimed to investigate haloperidol in combination with midazolam sedative properties to reach the most optimal dental treatment for uncooperative children. This study was designed as a randomized clinical study based on evaluating the efficacy and safety of two sedative methods. The sedative methods efficacy and safety were evaluated using behavioral and vital signs assessments during pulpotomy on primary molars. 60 Healthy non-cooperative children, aged 3-6 years, were divided into two equal groups according to the sedative methods: Group 1 (experimental): oral sedation with haloperidol 0.4 mg/kg in combination with midazolam 0.5 mg/kg, and Group 2 (control): oral sedation with midazolam 0.5 mg/kg. The behavior of the children subjected to the combination sedation was better than children subjected to the sedation with midazolam according to the OSUBRS scale. The depth of sedation among children subjected to the combination sedation appeared to be higher than the depth of sedation among children subjected to the sedation with midazolam with a statistically significant difference, according to the UMSS scale. According to the Houpt scale, the results showed that the general behavior of children subjected to the combination sedation was better than children subjected to midazolam. The sedative effect of haloperidol in combination with midazolam combination was better than the single administration of midazolam.