Abstract : This study aimed to investigate haloperidol sedative properties compared with midazolam in the management uncooperative children during dental treatment. This study was designed as a randomized clinical study based on evaluating the efficacy and safety of two sedative methods. The sedative methods efficacy and safety were evaluated using behavioral and vital signs assessments during pulpotomy on primary molars. 60 Healthy non-cooperative children, aged 3-6 years, were divided into two equal groups according to the sedative methods: Group 1 (experimental): oral sedation with haloperidol 0.25 mg/kg, and Group 2 (control): oral sedation with midazolam 0.5 mg/kg. The behavior of the children subjected to midazolam oral sedation was better than children subjected to haloperidol oral sedation according to the OSUBRS scale. The depth of sedation among children subjected to midazolam oral sedation appeared to be higher than the depth of sedation among children subjected to oral haloperidol sedation with a statistically significant difference, according to the UMSS scale. According to the Houpt scale, the results showed that the general behavior of children subjected to the midazolam oral sedation was better than children subjected to haloperidol oral sedation. The sedative effect of oral midazolam was better than the oral haloperidol.