One of the effects of stroke is the occurrence of hemiparesis or paralysis which makes the patient bed rest for a long time, causing the risk of pressure injury. Several pressure injury prevention interventions have been mentioned in previous studies, but with varying methods and results. The purpose of this study was to determine the effectiveness of using an air cushion and a 300 lateral position in reducing the risk of pressure injury in stroke patients. This study uses a quasi-experimental method with pre and post-test with a control group design. The minimum sample size required is 17 patients for each group (intervention and control). The group was given a combination of air cushion and right and left lateral position 300, while the control group was given daily intervention (standard) ward maintenance. The duration of the intervention was 3 days. Assessment of the risk of pressure injury using the Braden scale, and monitoring of changes in position using the observation sheet. Pressure ulcer risk assessment is carried out every morning. The data were statistically tested using the Wilcoxon test and the Mann-Whitney-U test. Data analysis showed that the combination of an air cushion and a 30º position effectively reduced the risk of injury p-value of 0.035 (<0.05). While the control group obtained a p-value of 0.480 (> 0.05), which means that the daily intervention by the control group nurse proved ineffective in reducing the risk of pressure injury in stroke patients. The Mann-Whitney test obtained a p-value of 0.009, meaning that the combination of an air cushion and a 30º lateral position in stroke patients with bed rest was effective in reducing the risk of pressure injury compared to the control group. This study proves that the prevention of pressure injury by giving a combination of air cushions and a 30° lateral position is effective for at least 3 days.