The number of patients being treated for end stage renal disease (ESRD) increased worldwide at a significant high rate. the Prevalence of ESRD in Egypt has amplified, Chronic kidney disease-mineral and bone disorders (CKD-MBD) are predominant in patients undergoing maintenance dialysis. Evaluate morning hemodialysis compared to night hemodialysis as regard to Bone Mineral Disease, hemodialysis adequacy and complete blood count allowing to participate in improving the outcome of hemodialysis(HD) patients. Cross-sectional study was conducted on 60 patients who settled in our dialysis units at Nephrology and UrologyUnit/ Minia University Hospital at both morning dialysis shift at (8am: 12pm) and evening shift (5pm: 9pm). There were statistically significant difference between the two hemodialysis shifts as regard to period of hemodialysis and number of medications taken by them and number of sessions per week and in corrected Calcium level (p value= 0.001 ,0.007, 0.014 and 0.031 respectively). Night hemodialysis was significantly higher in patients living in urban areas and Prevalence of uncontrolled diabetes (p< 0.001& 0.028 respectively). There were statistically significant differences between the morning and night hemodialysis patients regarding to period of hemodialysis, number of medications ,number of sessions per week and corrected Calcium level.