Complications of diabetes are commonly found including the decreased sexual ability for diabetic patients. A plant that is efficacious as an aphrodisiac and is known by people in South Sulawesi is the sanrego plant (Lunacia amara). The aim of this study is to determine the aphrodisiac effect of the ethanol extract of sanrego stems on diabetic rats induced by a high-fat diet. The research method was the post-test method by extracting sanrego stems with ethanol solvent, Wistar rats were fed a high-fat diet for 24 weeks, then HbA1C levels were measured. Rats that experienced insulin resistance continued to the research stage of the aphrodisiac effects of Sanrego which employed four male rats and 16 female rats for animal testing which were divided into four treatment groups. Each group consisted of one male rat and four female rats. Group I was given 1% Na-CMC (negative control), group II was given sildenafil citrate suspension (positive control), group III was given 100 mg/kg BW sanrego stem extract suspension, and group IV was given 150 mg/kg BW sanrego stem extract suspension. It was given orally for seven days and observations were conducted to see how many times the male rats had coitus after 4 hours of treatment. The results of statistical analysis using ANOVA with Duncan's advanced test showed that the administration of ethanol extract of sanrego stem at a dose of 100 mg/kg and 150 mg/kg BW had an aphrodisiac effect compared to Na-CMC as a negative control. Meanwhile, the ethanol extract of sanrego stem at a dose of 100 mg/kg BW and 150 mg /kg BW showed that there was a highly significant difference with sildenafil citrate.