This study aimed to evaluate the effect of modified bioactive glass (BioMin-F and BioMin-C) on at-home bleaching efficacy using 20% carbamide peroxide (CP) in terms of color change. A randomized double-blinded controlled clinical trial was conducted to measure the tooth color change of 30 patients after 1 week, 2 weeks, 1 month, 3 months, and 6 months of follow-up. The participants were instructed to apply 20% CP 4 hours a day for 14 days followed by applying either BioMin-F, BioMin-C, or a placebo paste 30 min a day for 14 days using a bleaching tray. Lightness (L*), redness (a*), and yellowness (b*) were measured using a digital spectrophotometer, and the overall color changes (ΔE) were calculated. ΔE values were statistically analyzed using the Kruskal-Wallis test. No significant differences were detected between BioMin-F, BioMin-C, and placebo groups regarding the ΔE (p-value >0.05). The modified BAG toothpaste (BioMin-F and BioMin-C) did not affect the color change induced by the at-home bleaching process.