Hyperemesis gravidarum is a severe persistent nausea and vomiting disorder during pregnancy that can lead to many problems. Several predisposing factors play a role in the pathophysiology of hyperemesis gravidarum but there is no definite relationship between them that has been proven until now including pro-inflammatory factors. Acupressure is thought to suppress the effects of proinflammatory cytokines that trigger the production of hCG, which is one of the triggering factors for hyperemesis gravidarum. Pregnant women with hyperemesis gravidarum who are treated according to the standard care for hyperemesis gravidarum are given acupressure stimulation during the first 48 hours of the treatment. Serum interleukin 6 (IL-6) levels and PUQE scores were measured at the start and end of stimulation. Serum IL-6 levels were significantly decreased in patients stimulated at the PC6 point compared to the Sham point (p < 0.05). This shows that acupressure stimulation at the PC6 point reduces IL-6 levels in pregnant women with hyperemesis gravidarum. Likewise, the decrease in PUQE scores was significantly different in patients stimulated at the PC6 point compared to the Sham point (p<0.05). Decrease in IL-6 had a strong correlation with the PUQE score (p = 0.016) which means that the decrease in IL-6 levels was followed by a decrease in the PUQE score. Acupressure stimulation at PC6 point can reduce IL-6 levels to accelerate the improvement of nausea and vomiting complaints in hyperemesis gravidarum.