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Abstract : Breast cancer has been one of the most prevalent cancers in women worldwide for more than ten years. The current study's objective was to assess DPG's preventive capabilities against DMBA-induced mammary cancer. The rats in this investigation were randomly categorized into six groups i.e. (I) Normal group; (II) was treated with 80 mg/kg b.w. DMBA for 4 weeks; (III and IV) DMBA + DGG (8 and 16 mg/kg); (VI) DMBA + tamoxifen (2 mg/kg.b.w) four weeks starting from the fifth week of DMBA administration, respectively. A significant normalization in plasma IL-2, IL-6, and IL-10 and TGF-β1 as well as mammary on mammary GSH, NP-SH, SOD, CAT, MDA and VEGF levels has been observed through in DMBA-treated rats when administrated with PDG. Oral DPG administration has suppressed PI3K, AKT, and STAT3 gene expression in DMBA-treated rats. The present biochemical and histological results showed that DPG has strong anticancer properties against DMBA-induced rat mammary carcinoma by induction the biosynthesizes of GSH, SOD, and CAT and suppressing the PI3K, AKT and STAT3 gene expression.