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Abstract :

Migraine is a common disabling brain disorder. Approximately 1% of the world’s population may have chronic migraine. Cerebral hemodynamics during different phases of the migraine attack demonstrate alterations in cerebral blood flow and perfusion, vessel caliber, cortical and sub-cortical function, underscoring that migraine pathophysiology is highly complex. Transcranial dopplerography assessment of blood flow parameters in patients with migraine. A retrospective analysis of the results of TransCranial Dopplerography (TCD) of the middle cerebral artery and main cerebral veins was performed in 117 patients with migraine-54 with aura and 63 without aura. The age of the subjects was 18-43 years, among them 53 (45.3%) men and 64 (54.7%) women. The maximum Systolic Velocity (Vs), the Resistance and Pulsativity Indexes (RI, PI) in Middle Cerebral Artery (MCA) the maximum systolic velocity in Basal Vein of Rosenthal (BVR) and in the Direct Sinus (DS) were determined. According to MRI data, structural changes in white matter of the brain were detected in 19 (30.2%) patients with migraine without aura (1st group) and 28 (51.9%) patients with migraine with aura (2nd group). The Vs in MCA among patients of 1st group averaged 127.9±6.8cm/c, in the patients of 2nd group - 61.7±5.7cm/c, in the control group - 108.4±6.1cm/c respectively. The Vs in a patient of 1st group were significantly higher than in patients of 2nd group and control group (P1-2<0.001, P1-2<0.001). The value of Vs was significantly lower than in the control group (P2-3 <0.001). In the first group, the value of RI was significantly (P1-2<0.05) less than in the second group. The value of PI in patients with migraine with aura was significantly higher (P<0.05) than in the group with migraine without an aura and a control group. The highest systolic blood flow velocity and asymmetry in the basal vein of Rosenthal was noted in patients of 1st group and amounted to 46.4±5.7cm/s, in the 2nd group - 27.8±4.6cm/s, in the control group - 21.4±3.8cm/c, respectively. The value of Vs among patients of 2nd group with high reliability (P 2-1<0.01, P 2-3<0.001) exceeded the rate in patients of 1st group and control group. In patients with migraine without an aura in the fetal period, the systolic blood flow velocity in the middle cerebral artery increases, the resistance index decreases. In patients with migraine with aura, the greatest increase in systolic blood flow velocity in the direct sinus is observed.