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Abstract : Health workers and hospital workers are the backbone of health services in hospitals. Hospitals are labor intensive, technology intensive, have a high level of human involvement, activities are continuous every day, and there are potential biological hazards, one of which is Tuberculosis (TB) bacteria. WHO Global TB Report 2020 data, Indonesia country no. 2nd highest in the world infected with Tuberculosis. For this reason, hospitals are workplaces with high occupational safety and health (OHS) risks. Aims: to develop an intervention model to protect hospital workers from tuberculosis infection. The type of research carried out was operational research with a quantitative and qualitative approach. The population and sample for this study were workers in 7 hospitals in 5 provinces who contributed more than 50% of the notifications of tuberculosis cases, totaling 700 respondents. Tuberculosis is an occupational health problem among hospital workers. Workers are a population at risk of being infected with TB but there is no official data regarding TB cases among workers in Indonesian hospitals. In order to reduce TB exposure in health care facilities, it is necessary to build an infection control system to ensure the health of the workforce and reduce TB transmission in hospitals. Existing policies do not clearly regulate occupational TB in hospital workers, legal sanctions, ongoing supervision by the hospital infection control prevention team, compensation and reporting of TB cases in hospital workers. Instrument for efforts to protect hospital workers from tuberculosis infection.