Abstract : The early-onset colorectal cancer (EO-CRC) prevalence has been steadily rising worldwide, which has led to it becoming a major public health concern. This condition may be a distinct entity with a higher degree of aggression based on its clinical, genetic, molecular, and histological features. However, it seems that the observed epidemiological change in the incidence of colorectal cancer (CRC) is influenced by both environmental and genetic risk factors. To clarify the aetiology of EO-CRC and develop efficient screening and management strategies, more data is needed. Given that colorectal cancer may cause the greatest loss of years of life in this demographic at the time of diagnosis, managing the disease in young adults represents an unmet clinical need. Since early 1990, the yearly incidence of colorectal cancer (CRC) in individuals under 50 has increased at a rate of 2%. Particularly concerning is the rise in the disease's incidence among young adults, as the overall frequency of CRC has been declining. The left side of the colon is home to the primary tumour of early-onset colorectal cancer (CRC), which is linked to worse cell differentiation, a higher incidence of signet ring cell histology, and an advanced stage at diagnosis. About 30% of patients have tumours containing mutations that result in hereditary cancer predisposing syndromes, and 20% of patients have familial colorectal cancer (CRC). About 30% of patients have tumours containing mutations that result in hereditary cancer predisposing syndromes, and 20% of patients have familial colorectal cancer (CRC).