Critical thinking requires distinguishing between statements of truth, judgment, and opinion. Critical thinking demands the nurse to plan ahead, apply thought while acting, and reflect in retrospect, which is known as reflective thinking. Creativity in problem-solving and decision-making is the capacity to create and implement novel and superior healthcare solutions. To assess the knowledge of nurses related to application and analysis concepts (pre-test). To evaluate nurses’ knowledge related to application and analysis concepts (post-test). Between 10th October 2020 and 30th August 2022, a quantitative study utilizing a pre-test and post-test methodology and a quasi-experimental design was done to examine the impact of a critical thinking educational program on the knowledge of nurses. A non-probability purposive sample was chosen for this study's sample according to the crucial role of nurses in the critical care units in Al-Hillah Teaching Hospitals. The present study confirmed the study’s findings including the majority of nurses of both groups were in middle adulthood, between (25-29) The majority of the participants in the interventional and control group, (77.8%), (66.7%) were female nurses, (50%) of the control group were married and (63.9%) from the interventional group were single. Related to years of experience the results show that the high percentage in both groups 32 (88.9%), and 24(66.7) were with 3 years or less. The majority of participants in the study exhibited similar demographical (age, gender, marital status) and occupational characteristics (years of experience for nurses). The knowledge of the nurses who participated in the critical thinking educational program increased following its implementation compared to their total pre-intervention evaluation. Enhance nurses’ knowledge and skills using self-learning packages and online-learning courses. Conduct longitudinal research designs that will enable future researchers to track nurses’ critical thinking developed over the course of their entire undergraduate careers.