Corneal biomechanics has been heavily investigated by researchers due to its potential applications in the diagnosis, management, and treatment of several pathologies such as corneal ectasia, refractive surgery, and glaucoma. In the case of corneal ectasia, crosslinking is an effective method to slow or halt the progression of the disease. In 2016, the U.S. Food and Drug Administration (FDA) gave clearance for the crosslinking system to treat patients with progressive keratoconus and post-LASIK (laser-assisted in situ keratomileuses). This review discusses the latest development of Scheimpflug corneal tomography to assess the efficacy of crosslinking and to detect the progressivity of keratoconus in patients post-crosslinking. Corvis-ST is a non-contact tonometry system that allows the assessment of corneal biomechanical properties. The integration of these data into artificial intelligence has demonstrated to improve the accuracy to assess crosslinking efficacy.