Abstract : Dengue fever, caused by dengue viruses (DENV) and transmitted by Aedes mosquitoes, is a major global health concern, especially in tropical and subtropical regions. This study focuses on the hemodynamic changes and liver function alterations in adult dengue patients exhibiting plasma leakage, a hallmark of severe forms of dengue such as dengue haemorrhagic fever (DHF). Plasma leakage can lead to hypovolemic shock and severe organ dysfunction, including liver injury, which plays a critical role in the disease's clinical severity. The study was conducted as collaborative research by Era’s Lucknow Medical College and Hospital, Era University and American University of Barbados school of Medicine, Barbados involving 30 adult dengue patients, with a focus on those showing clinical or laboratory evidence of plasma leakage. Hemodynamic parameters, including blood pressure, heart rate, and packed cell volume (PCV), were closely monitored. Liver function was assessed through daily measurements of serum transaminases (AST, ALT), bilirubin, and other liver function tests. Thrombocytopenia (low platelet count) was observed in 76.6% of patients, with both male and female patients showing significant reductions in platelet levels. Among the patients, elevated serum transaminase levels were common, with SGOT (AST) elevated in 96% of cases and SGPT (ALT) elevated in 90%, indicating widespread liver dysfunction. The study found a correlation between increased PCV, signifying plasma leakage, and elevated liver enzymes, particularly in those with more severe disease, including the two cases of DHF. One male and one female patient demonstrated progression to dengue haemorrhagic syndrome, with both showing marked increases in PCV and liver enzyme levels over time. These findings underscore the importance of monitoring both hemodynamic stability and liver function in dengue patients with plasma leakage. Understanding this relationship may guide more effective clinical management strategies to reduce the severity and mortality associated with severe dengue.