Abstract : Metabolic disorders were a significant health issue for many adults with congenital heart disease, but the variations in metabolite levels related to metabolic syndrome between Asian adults with congenital heart disease and the healthy population were not known. The aim of this study is to compare lipid levels between congenital heart disease patients and control group in Asian adults. This systematic review and meta-analysis was performed according to PRISMA 2020 guidelines. A literature search was conducted through PubMed, ScienceDirect, and Cochrane Library selecting observational studies until July 2024. The studies showed lipid levels in Asian adults with congenital heart disease. Meta-analysis was conducted using R Studio 4.3.2 software. In total, 6 observational studies (4 studies for meta analysis) involving 434 patients with congenital heart disease and 405 controls were eligible for this review. The quantitative analysis showed that patients with congenital heart disease have lower levels of total cholesterol (MD: -2.57 [95% CI: -5.00 to -0.14]; p=0.038), LDL-C (MD: -1.58 [95% CI: -3.26 to 0.10]; p=0.065) and HDL-C (MD: -0.86 [95% CI: -1.14 to -0.58]; p<0.001) compared to controls. Total cholesterol and HDL-C in Asian adults with congenital heart disease were significantly lower than those in the control group. New research should be developed to clarify this relevant topic.