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Abstract : Endodontic treatment success hinges on the effective elimination of bacteria from the root canal system. Bacterial persistence, primarily due to inadequate chemo mechanical preparation or suboptimal filling, is a leading cause of treatment failure. Enterococcus faecalis, a bacterium resistant to many irrigation solutions, has been identified as a primary culprit. Mechanical preparations alone fail to eradicate such bacteria, necessitating the use of effective chemical agents. While Sodium Hypochlorite (NaOCl) is the most widely used, its drawbacks, such as potential toxicity and inability to kill all microorganisms, have directed attention towards alternative solutions like Chlorhexidine Plus (CHX-Plus) and Chloramine-T. This study aimed to assess the efficacy of 2% Chloramine-T in eliminating Enterococcus faecalis from root canals, and to Evaluate the potency of Chlorhexidine Plus against Enterococcus faecalis within inoculated root canals. 40 human mandibular first molars were divided into two groups based on the irrigation solution used: Chlorhexidine Plus and 2% Chloramine-T. After irrigation, bacterial samples were extracted and cultured to determine the remaining bacterial colony count. The data were subjected to statistical analysis to assess the difference in bacterial counts before and after irrigation. In the aerobic bacterial group treated with Chloramine T, the average bacterial colony count reduced from 163,000 to 890. In the group treated with Chlorhexidine Plus, the count decreased from 163,000 to 14. For anaerobic bacteria, Chloramine T reduced the count from 164,000 to 1,400, while Chlorhexidine Plus brought it down from 163,000 to 12. The paired sample t-test showed a significant difference in bacterial counts before and after irrigation for all groups. Both Chloramine-T and Chlorhexidine Plus exhibited substantial antimicrobial efficacy against Enterococcus faecalis in root canals, with Chlorhexidine Plus showing a slightly better performance. These findings highlight the potential of these solutions as alternatives or supplements to Sodium Hypochlorite in endodontic treatments.