Abstract : Breast masses are a common clinical concern in women, requiring careful evaluation to differentiate between benign and malignant lesions. While clinical examination and imaging modalities such as ultrasound and mammography play a central role in diagnosis, the psychological impact of breast mass evaluation, including anxiety, fear, and distress, is increasingly recognized as a critical aspect of patient care. This retrospective cross-sectional study was conducted at Al-Mouwasat University Hospital between 2022 and 2024. A total of 823 patients with breast masses who underwent ultrasound evaluation, and for those over 40 years, mammography as well, were included. Clinical data, imaging findings, biopsy results, and psychological manifestations were collected from patient files and telephone interviews. Patients not followed in the hospital were excluded. Ultrasound, Doppler, and digital mammography were used for radiological assessment, with images archived in the PACS system. Biopsies were performed when indicated, and histopathological findings were reviewed. Patients were distributed across age groups, with 15% aged 29, 10% aged 30–39, 25% aged 40–49, 25% aged 50–59, and 25% aged 60–75. Clinical examination revealed that 70% of patients self-detected breast masses, while 87% were detected on clinical palpation. Nipple discharge, nipple retraction, and peau d’orange were observed in 10–35% of cases. Ultrasound detected normal findings in 28% and characterized benign masses according to echogenicity. Microcalcifications were noted in 30% and coarse calcifications in 70%. Biopsy results showed 54% benign fibroglandular lesions, 17% inflammatory changes, 20% normal findings, and 9% malignant lesions. Psychological evaluation revealed anxiety, fear, and depression in 40–50% of patients, particularly during mammography (66%). BI-RADS classification correlated well with histopathology, with BI-RADS I–II predominating in benign cases and BI-RADS IV–V associated with malignancy. The integration of clinical, radiological, and psychological assessments enhances diagnostic accuracy and patient care in breast mass evaluation. Early detection through combined imaging modalities, supported by attention to psychological well-being, improves patient outcomes and adherence to management plans. The study findings are consistent with international guidelines and highlight the need for a multidisciplinary approach in breast care.