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Abstract : Bone is a metabolically active tissue that undergoes continuous regeneration, namely formation and resorption of bone. Bone regeneration is essential for bone homeostasis. Bones must be in constant condition, which is important for the maintenance of normal skeletal structure and function. Food ingredients are needed that can help maximum bone growth, such as anchovies. Anchovies are a source of calcium which is needed in the formation and regeneration process of bones. To determine the potential of anchovy (stolephorus sp.) for mandibular bone regeneration through BMP2 expression. The type of research is laboratory experimental with a posttest only control group design. with a total sample of 27 male Wistar rats (rattus norvegicus) divided into 3 groups. Testing the effectiveness of bone regeneration in experimental animals through immunohistochemical examination using the ELISA technique. The research results were analyzed statistically with a normality test using the Shapiro-Wilk test showing a significant value (p>0.05) meaning the data was normally distributed. The results of statistical tests using the independent sample t-test showed a value of (p<0.05), which means there was a significant difference in BMP2 levels in the anchovy group and the negative control group, but when compared between the anchovy group and the positive control group, it showed no difference in BMP2 levels. significant with a value (p>0.005). Giving anchovies can increase mandibular bone growth in the treatment group. There is a positive correlation between giving anchovies and the amount of BMP2 expression. Further research using different doses and other types of measurements needs to be carried out to determine the potential for mandibular bone regeneration.