This study was aimed to determine association between UGT1A1 polymorphism and hyperbilirubinemia among neonates. We conduct searching from PubMed, ProQuest, ScienceDirect, WileyOnline, and Cochrane while applying selection criteria. There were four eligible studies which were good after appraisal using Newcastle-Ottawa scale. Qualitative analysis found there was more UGT1A1 c.3279T>G polymorphism alongside with less expression of UGT1A1 c.189C>T polymorphism in hyperbilirubinemia group. Polymorphism of UGT1A1 c.211G>A and (TA)7 were variative throughout studies, hence quantitative analysis was conducted. There was less c.211G>A GG expression (OR 0.39, 95% CI 0.21–0.71), and more c.211G>A GG GA and c.211G>A GG AA expression with odds ratio of 2.95 (95% CI 1.52–5.70) and 8.06 (95% CI 1.43–45.33) respectively. However, there was insignificant difference noted in UGT1A1 (TA)7 polymorphism and its subtypes (77, 76, 66). Qualitative analysis shown that insignificant difference was also noted in UGT1A1 (TA)7 polymorphism. Therefore, it could be concluded that UGT1A1 polymorphism, especially c.211G>A and (TA)7 was associated with hyperbilirubinemia in neonates.