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Abstract : Thalassemia major is caused by a mutation in the beta globin gene that impair the production of beta globin chain. There is increased survival of patients with beta thalassemia major due to effective chelating treatment also safe blood transfusion system. This leads to increase to have hepatocellular possibility. In this study 47 patients with beta thalassemia major were randomly selected and Hemoglobin (Hb), White blood cell (WBC), platelets, ferritin level and tumor markers alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) were investigated. The results indicated there is a positive correlation of serum ferritin with age of patients and only 4 of them have high AFP while for CEA 5 patients have high level. Inconclusion, patients with beta thalassemia with duration time more than 10 years should check these tumor markers to avoid any consequences in the future.