This study was to assess and compare antibiotic consumption on orthopedic patients by Defined Daily Dose (DDD). ATC/DDD system is a method of counting the amounts of drugs recommended by WHO and Ministry of Health which useful for monitoring and comparing antibiotic use among departments, within hospital, as well as between countries or regions. A literature review was conducted by searching articles through PubMed, Scopus, Cochrane Library, and Google Scholar database up to November 2020 using several keywords. After thousand articles were identified, sixteen articles met the inclusion criteria. The value of DDD on orthopedic unit were various from 22.30 to 212.7 DDD/100 patient-days. The most widely used antibiotic for prophylaxis was Cefazolin, with the value of 984.76 DDD/100 operations. Whereas cephalosporin were found to be the most antibiotic used for therapeutic, with the value of 45,5-52,5 DDD/100 patient-days. The antimicrobial stewardship program showed a decrease in the use of antibiotics, but it is not the only parameter to assess the wise use of antibiotics. In Conclusions, the antibiotic use was found very high on orthopedic patients, especially as prophylaxis antibiotic. The quality of antibiotic use may be improved through better compliance with guideline and implementation of antimicrobial stewardship program.