Diabetes mellitus is a progressive disease that can cause various complications, both acute and chronic if not managed properly. resulting in various chronic complications, such as cerebrovascular disease, coronary heart disease, leg vascular disease, eye, kidney and nerve disorders. People with diabetes mellitus have a 2 times greater risk of developing coronary heart disease and cerebral vascular disease, 5 times more likely to suffer from ulcers/gangrene, 7 times more likely to develop terminal renal failure, and 25 times more likely to be blind due to retinal damage than patients. non-diabetic. The purpose of this study was to determine the effect of the application of stress management on the quality of life of people with Diabetes Mellitus in the Diabetes Center, Ternate City. This research was conducted in the working area of the Diabetes Center, Ternate City. The design of this study was a quasi-experimental study, which was a pre and post-test design without a control group. Participants in this study were selected using a technique using simple random sampling with a total sample of 61 people, where the data were analyzed using the t-test statistical test, Anova and correlation. The results of the study found that there was a significant difference between the quality of life of DM sufferers before and after the application of stress management. The patient's quality of life score also increased after stress management was carried out in the form of deep breath relaxation techniques and five-finger hypnosis (p-Value: 0.0005 α: 0.05), while the characteristics of the respondents included gender, marital status, education, family history, and medication do not affect the quality of life.