According to the World Health Organization (WHO), chronic disease is a disease with a long duration that generally develops slowly and results from genetic, physiological, environmental, and behavioral factors. Globally, regionally and nationally. In 2030, there will be an epidemiological transition from communicable diseases to non-communicable diseases. This study aims to determine factors related to the use of chronic disease programs in Sorong City. This research is an analytic observational study with a cross-sectional study design. The number of samples is 197 samples. The sampling technique uses Proportional Random Sampling. Data analysis used SPSS version 26 with chi-square and multiple logistic regression. The results showed that significant factors for the utilization of chronic disease programs (prolanis) were age (p=0.028), knowledge (p=0.007), family support (p=0.049), and support from health workers (p=0.007). The results of the Multivariate analysis that were most related were knowledge (p=0.003) and health worker support (p=0.005). The most dominant factor is the Knowledge variable. Health center staff can provide clear and accurate information related to the diseases suffered by prolanis participants by giving prolanis participants a longer consultation time.