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Abstract : Amoebiasis is an enteric protozoan disease of the human gastrointestinal tract caused by E. histolytica, which is a public health problem in many developing countries. Especially in poor sanitation areas. The study aimed to estimate some immunological parameters in symptomatic amoebic children. The study was conducted in the Pediatric Teaching Hospital in Sulaymaniyah province during September - December 2021. The serum was taken from 80 amoebic infected children (patient group) and 80 parasite-free children (control group) for estimating IL-17, IFN- γ, and TNF-α levels by applying the ELISA technique and for CRP estimation using Cobas-C311. A highly significant difference was recorded in the serum concentration of CRP between the patient group and the control group (P<0.001). The serum concentration of IL-17 was not significantly different between the two studied groups (P>0.05); however, IFN-γ level was reported to be significantly different (P≤0.05), and TNF-α serum level noted a highly significant difference (P<0.001). The highest level of IL-17 was recorded in infected males compared to the females, with a significant difference. Regarding age and blood group, no significant difference was recorded in infected children. The immunological measurement of CRP and TNF-α revealed a highly significant difference in the patients compared to the controls, and the serum level of IFN-γ documented significant differences. Also, significant differences were recorded in serum IL-17 among infected children of different ages.