Type 2 diabetes mellitus (T2DM) implies the highest incidence of diabetic cases. T2DM is related to metabolic ailments in the pancreas, kidneys, liver, and intestines. To determine the impact of adherence to antidiabetic medication (ADMs) on glycemic control in T2DM patients. This cross-sectional study enrolled 245 participants (119 intervention patients and 126 non-intervention patients) with T2DM in Diabetes and Endocrine Center, Sulaimaniyah, Iraq, from January to August 2021 through direct interviews using a special self-created questionnaire. Information leaflets and medication counselling were provided to the intervention group by the researcher. ADMs was evaluated using the Morisky Medication Adherence Scale item 8 (MMAS-8). Also, fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c%) were checked to assess glycemic control among the participants. The counselling program improved ADMs potentially as the rate of medium adherence increased significantly from 5.0% to 31.9% (p<0.001), with a significant perfection in glycemic control in the intervention group from 13.9% (before the intervention) to 21.8% (after the intervention) (p=0.039). However, there was no significant difference between ADMs and glycemic control (p>0.999). Patients’ education and medication counselling significantly improved ADMs and glycemic control in people with T2DM.