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Abstract : The relationship between diet and acne has been controversial. Recently, there has been a surge in studies providing greater insight, with several studies looking into glycaemic index (GI), diet and their relationship with acne vulgaris. To assess the Glycaemic index, lipid profile and compare it with acne grade. Study was conducted from Dec 2020 to May 2022.Where a total of 150 acne patients were enrolled. Patients were examined and grade of acne was established along with blood sample (for lipid profile) and a questionnaire to assess their meal patterns were collected (International Glycaemic index charting) dividing them into high, moderate and low Glycaemic index. This data was compared with the grade of acne. 46.7% of the study subjects had grade 1 acne, 46.3% of them had grade 2 acne and only 8% of had grade 3 acne. 64%(breakfast), 22.7% (lunch), 23.4% (dinner) had low glycaemic index. 22.7%(breakfast), 50.7%(lunch), 47.3%(dinner) had medium glycaemic index. 13.3%(breakfast), 26.7% (lunch), 26.7% (dinner) had high glycaemic index. Patient with higher grade of acne showed to have high Glycaemic index diet. The mean value of total cholesterol was 128.04 ±33.94 in mild acne, 127.63 ± 33.4 in moderate acne and 129.34 ±34.22 in severe acne, other markers of lipid profile (LDL, VLDL, HDL, Triglycerides) showed similar corelation. We noted a significant association of lipid profile and glycaemic index in acne severity.