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Abstract : Because numerous various germs are discovered on their surface during orthodontic treatment, detachable orthodontic and orthopedic appliances cleaner demands careful hygiene. About 60 samples with dimension (45*10*1.5mm length, with thickness) were used for the color test by spectrophotometer device, and 60 samples with dimension (30*10*3mm length width thickness) were used for the hardness test by shore A hardness device. The orthodontic appliance should be cleaned after each meal time for about half an hour three times per day to stay clean without stain, food accumulation, and to keep consequences of staind appliance away like gingivitis and candidiasis sore throat, So to make the cleaning simulation cycle, we soaked these samples in cleanser solutions for ½ hour three times per day after each cleaning once we put the samples in r.o. water. every day we repeat the cleaning procedure for about two months. For the color test, We measured the absorbance at the beginning of the study, and after two months maximum absorptions of visible light by acrylic resin occurred at the wavelength (345nm).so, for the hardness test we measure it after two months and compare it with the control solutions. The experimental results showed that the Interquartile range at the Preclean color for (hydrogen peroxide 6%) was 0.32 compare to water and tablet (0.11, 0.10) respectively, compare to the Post-clean color (0.28, 0.20), So the results showed the Interquartile range of Hardness about (4.71, 3.95) respectively for two groups (4gm soda+ 4.5 g citric and 2gm soda+ 6.14 g alum), whilst 3.15 for three groups (2gm soda+ 4.5 g citric, 1gm soda + 6.14 g alum and 50%H2O2), When the comparison of (precleaning and post-cleaning color) by using Wilcoxen signed ranks test between all groups, as well as results showed (P-value <0.05) for all groups except water as (P-value >0.05), so results of the current study showed significantly (p<0.05), when Comparing solution post-cleaning color with water and tablet by using of Mann whiteny test.so the tablet versus water there was a change in color and the difference was statically significant (p-value = 0.07 > 0.05). Color: Soda+ citric acid solutions of different conc. Of soda have no diverse effect on the color of acrylic resin. Soda + alum increase color density, H2O2 decrease color density (bleaching effect), In comparison with water and tablet. Hardness: Both of them (Soda +citric, Soda+alum) have no diverse effect on hardness of acrylic resin, H2O2 increase hardness of acrylic resin because leach out of plastisizer. The best cleanser solution that have no effect on the color and hardness of acrylic resin speciment is (soda + citric acid) with different conc.