Abstract : A quasi-experimental study was conducted in 2019 in 3 (three) districts/cities (Palu City, Sigi Regency, and Donggala Regency) in Central Sulawesi. This research was conducted to increase the knowledge and skills of midwives in the detection of pre-eclampsia, to increase referrals for pregnant women with pre-eclampsia to district/city hospitals, and to improve supervision of midwives in the detection and referral of pre-eclampsia cases by universities (the divisions of Public Health Sciences and Community Medicine). Intervention through education and training on quality of antenatal care focusing on Pre-Eclampsia using updated training modules. There were 75 health center midwives in 3 research locations who participated in the research and were assisted by co-assistant students (junior doctors) who held positions in the Public Health Sciences and Community Medicine departments of the Faculty of Medicine, Tadulako University. In this study, data were collected from patient registers, monthly reports from the community health center, semi-structured questionnaires to obtain knowledge, checklists for observing skills in screening for pre-eclampsia, measuring blood pressure and urine protein (dipstick test), as well as monitoring/observation forms of adherence midwife. The results showed an increase in knowledge before and after the intervention (p <0.001) and an increase in skills (p <0.001), including skills for screening, measuring blood pressure, and checking urine protein. There was an increase in pre-eclampsia cases referred after the intervention, from 2.39% to 3.56% (p <0.001). In this study, data were collected from patient registers, monthly reports from the community health center, semi-structured questionnaires to obtain knowledge, checklists for observing skills in screening for pre-eclampsia, measuring blood pressure and urine protein (dipstick test), as well as monitoring/observation forms of adherence midwife. The results showed an increase in knowledge before and after the intervention (p <0.001) and an increase in skills (p <0.001), including skills for screening, measuring blood pressure, and checking urine protein. There was an increase in pre-eclampsia cases referred after the intervention, from 2.39% to 3.56% (p <0.001).